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FOR THE RECORD

H-bonding mediates polarization of peptide groups in folded proteins

Nenad Jurani, Slobodan Macura and Franklyn G. Prendergast

Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA

Reprint requests to: Nenad Jurani, Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Clinic and Foundation, Rochester, MN 55905, USA; e-mail: juranic.nenad{at}mayo.edu.

The carbon-nitrogen J-couplings in the hydrogen bonding chains of proteins show that H-bonding mediates peptide-group polarization, which results in the general reduction of peptide-group polarity of folded proteins in solution. The net effect is to make large regions of protein secondary structure, especially ß-sheets, intrinsically more hydrophobic, contributing thereby to overall stability of the tertiary structure.

Keywords: Protein H-bond networks; peptide-group polarizations; NMR spin-spin coupling

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