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Published online before print January 10, 2004, 10.1110/ps.03401004
Protein Science (2004), 13:545-548. Published by Cold Spring Harbor Laboratory Press. Copyright © 2004 The Protein Society
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FOR THE RECORD

Solution structure of a BolA-like protein from Mus musculus

Takuma Kasai1,2, Makoto Inoue1, Seizo Koshiba1, Takashi Yabuki1, Masaaki Aoki1, Emi Nunokawa1, Eiko Seki1, Takayoshi Matsuda1, Natsuko Matsuda1, Yasuko Tomo1, Mikako Shirouzu1,3, Takaho Terada1,3, Naomi Obayashi1, Hiroaki Hamana1, Naoko Shinya1, Ayako Tatsuguchi1, Satoko Yasuda1, Mayumi Yoshida1, Hiroshi Hirota1, Yo Matsuo1, Kazutoshi Tani1, Harukazu Suzuki1, Takahiro Arakawa1, Piero Carninci1, Jun Kawai1, Yoshihide Hayashizaki1, Takanori Kigawa1 and Shigeyuki Yokoyama1,2,3

1 RIKEN Genomic Sciences Center, Yokohama, Japan
2 Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan
3 RIKEN Harima Institute at SPring-8, Hyogo, Japan

(RECEIVED September 1, 2003; FINAL REVISION September 1, 2003; ACCEPTED October 7, 2003)



Abstract

The BolA-like proteins are widely conserved from prokaryotes to eukaryotes. The BolA-like proteins seem to be involved in cell proliferation or cell-cycle regulation, but the molecular function is still unknown. Here we determined the structure of a mouse BolA-like protein. The overall topology is {alpha}{beta}{beta}{alpha}{alpha}{beta}{alpha}, in which {beta}1 and {beta}2 are antiparallel, and {beta}3 is parallel to {beta}2. This fold is similar to the class II KH fold, except for the absence of the GXXG loop, which is well conserved in the KH fold. The conserved residues in the BolA-like proteins are assembled on the one side of the protein.

Keywords: NMR structure; conserved protein; BolA; cell proliferation; cell-cycle regulation; KH fold; structural genomics

Reprint requests to: Shigeyuki Yokoyama, Protein Research Group, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan; e-mail: yokoyama{at}biochem.s.u-tokyo.ac.jp; fax: 81-45-503-9195.

Article published online ahead of print. Article and publication date are at http://www.proteinscience.org/cgi/doi/10.1110/ps.03401004.


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