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1 BioInfoBank Institute, Limanowskiego 24A/16, 60-744 Poznan, Poland
2 Center of Excellence in Bioinformatics and Computer Science and Engineering, University at Buffalo, Buffalo, New York 14203, USA
3 Bioinformatics, Department of Computer Science, Ben Gurion University Beer-Sheva 84015, Israel
(RECEIVED May 25, 2004; FINAL REVISION September 23, 2004; ACCEPTED September 23, 2004)
We present the results of the evaluation of the latest LiveBench-8 experiment. These results provide a snapshot view of the state of the art in automated protein structure prediction, just before the 2004 CAFASP-4/CASP-6 experiments begin. The last CAFASP/CASP experiments demonstrated that automated meta-predictors entail a significant advance in the field, already challenging most human expert predictors. LiveBench-8 corroborates the superior performance of meta-predictors, which are able to produce useful predictions for over one-half of the test targets. More importantly, LiveBench-8 identifies a handful of recently developed autonomous (nonmeta) servers that perform at the very top, suggesting that further progress in the individual methods has recently been obtained.
Keywords: protein structure prediction; LiveBench; CAFASP
Article and publication are at http://www.proteinscience.org/cgi/doi/10.1110/ps.04888805.
Reprint requests to: Daniel Fischer, Center of Excellence in Bioinformatics and Computer Science and Engineering, University at Buffalo, 901 Washington St., Suite 300, Buffalo, NY 14203, USA; e-mail: dfischer{at}bioinformatics.buffalo.edu; fax: (716) 849-6747.
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