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Published online before print September 9, 2005, 10.1110/ps.051516405
Protein Science (2005), 14:2741-2743. Published by Cold Spring Harbor Laboratory Press. Copyright © 2005 The Protein Society
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FOR THE RECORD

Crystal lattice as biological phenotype for insect viruses

Karin Anduleit1, Geoff Sutton1, Jonathan M. Diprose1, Peter P.C. Mertens2, Jonathan M. Grimes1 and David I. Stuart1

1 Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom
2 Institute for Animal Health, Pirbright Laboratory, Woking, GU24 0NF, United Kingdom

(RECEIVED April 15, 2005; FINAL REVISION June 24, 2005; ACCEPTED July 4, 2005)

Many insect viruses survive for long periods by occlusion within robust crystalline polyhedra composed primarily of a single polyhedrin protein. We show that two different virus families form polyhedra which, despite lack of sequence similarity in the virally encoded polyhedrin protein, have identical cell constants and a body-centered cubic lattice. It is almost inconceivable that this could have arisen by chance, suggesting that the crystal lattice has been preserved because it is particularly well-suited to its function of packaging and protecting viruses.

Keywords: insects; viruses; polyhedra; powder diffraction; crystals

Article published online ahead of print. Article and publication date are at http://www.proteinscience.org/cgi/doi/10.1110/ps.051516405.

Reprint requests to: David I. Stuart, Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; e-mail: enquires{at}strubi.ox.ac.uk; fax: +44-1865-287547.


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