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Protein Science (2005), 14:2759-2763. Published by Cold Spring Harbor Laboratory Press. Copyright © 2005 The Protein Society
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PROTEIN STRUCTURE REPORT

Crystal structure of the Yersinia type III secretion protein YscE

Jason Phan, Brian P. Austin and David S. Waugh

Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA

(RECEIVED July 15, 2005; FINAL REVISION July 15, 2005; ACCEPTED July 27, 2005)

The plague-causing bacterium Yersinia pestis utilizes a contact-dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. The type III secretion apparatus is composed of 20–25 different Yersinia secretion (Ysc) proteins. We report here the structure of YscE, the smallest Ysc protein, which is a dimer in solution. The probable mode of oligomerization is discussed.

Keywords: Yersinia pestis; plague; type III secretion; YscE; crystal structure

Article and publication are at http://www.proteinscience.org/cgi/doi/10.1110/ps.051706105.

Reprint requests to: David S. Waugh, Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702-1201, USA; e-mail: waughd{at}ncifcrf.gov; fax: (301) 846-7148.


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