Protein Science
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print October 31, 2005, 10.1110/ps.051821805
Protein Science (2005), 14:3121-3128. Published by Cold Spring Harbor Laboratory Press. Copyright © 2005 The Protein Society
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ps.051821805v1
14/12/3121    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sun, W.
Right arrow Articles by Christendat, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sun, W.
Right arrow Articles by Christendat, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

PROTEIN STRUCTURE REPORT

The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii

Warren Sun1, Xiaohui Xu2, Marina Pavlova2, Aled M. Edwards2,3,4, Andrzej Joachimiak5, Alexei Savchenko2 and Dinesh Christendat1

1 Department of Botany, University of Toronto, Toronto, Ontario M5S 3B2, Canada
2 Ontario Center for Structural Proteomics, University Health Network, Toronto, Ontario M5G 1L7, Canada
3 Structural Genomics Consortium and 4 Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
5 Midwest Center for Structural Genomics and Structural Biology, Argonne National Laboratory, Argonne, Illinois 60440, USA

(RECEIVED September 2, 2005; FINAL REVISION September 2, 2005; ACCEPTED September 7, 2005)

The S-adenosyl-L-methionine (SAM)-dependent methyltransferases represent a diverse and biologically important class of enzymes. These enzymes utilize the ubiquitous methyl donor SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids. Here we present the crystal structure of PH1915 from Pyrococcus horikoshii OT3, a predicted SAM-dependent methyltransferase. This protein belongs to the Cluster of Orthologous Group 1092, and the presented crystal structure is the first representative structure of this protein family. Based on sequence and 3D structure analysis, we have made valuable functional insights that will facilitate further studies for characterizing this group of proteins. Specifically, we propose that PH1915 and its orthologs are rRNA- or tRNA-specific methyltransferases.

Keywords: COG1092; crystal structure; methyltransferase; PH1915; S-adenosylmethionine

Article published online ahead of print. Article and publication date are at http://www.proteinscience.org/cgi/doi/10.1110/ps.051821805.

Reprint requests to: Dinesh Christendat, Department of Botany, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada; e-mail: dinesh.christendat{at}utoronto.ca; fax: (416) 978-5878.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by The Protein Society.