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Protein Science, Vol 3, Issue 5 853-856, Copyright © 1994 by Cold Spring Harbor Laboratory Press

FOR THE RECORD

A novel zinc-binding motif found in two ubiquitous deaminase families

J. REIZER, S. BUSKIRK, A. BAIROCH, A. REIZER and M. H. SAIER-JR.
Department of Biology, University of California at San Diego, La Jolla, California 92093-0116

Two families of deaminases, one specific for cytidine, the other for deoxycytidylate, are shown to possess a novel zinc-binding motif, here designated ZBS. We have (1) identified the protein members of these 2 families, (2) carried out sequence analyses that allow specification of this zinc-binding motif, and (3) determined signature sequences that will allow identification of additional members of these families as their sequences become available.
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