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Protein Science, Vol 3, Issue 6 982-983, Copyright © 1994 by Cold Spring Harbor Laboratory Press

FOR THE RECORD

Crystallization and preliminary structural studies of neurotrophin-3

J. A. KELLY, E. SINGER, T. D. OSSLUND and T. O. YEATES
Molecular Biology Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90024-1570

Neurotrophin-3 (NT-3) has been crystallized in 2 forms. Orthorhombic crystals, space group P2(1)2(1)2, diffracted to 2.8 A and have cell dimensions a = 39.1 A, b = 54.0 A, and c = 65.5 A. The second form is space group P4(3)2(1)2, with cell dimensions a = b = 67.1 A, and c = 107.9 A. The tetragonal crystals diffract to 2.8 A at room temperature and 2.5 A at -100{deg}C. The unit cell dimensions change significantly upon freezing, a = b = 66.1 A, and c = 102.8 A. Phases for the orthorhombic form were obtained by molecular replacement using nerve growth factor as the search model. A partially refined model of the NT-3 dimer (75% complete) was then oriented and positioned in the tetragonal cell.
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N. Q. McDonald and M. V. Chao
Structural Determinants of Neurotrophin Action
J. Biol. Chem., August 25, 1995; 270(34): 19669 - 19672.
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