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Protein Science, Vol 4, Issue 3 534-537, Copyright © 1995 by Cold Spring Harbor Laboratory Press
FOR THE RECORD |
V. C. GOSWITZ and R. J. BROOKER
Department of Genetics and Cell Biology and the Institute for Advanced Studies in Biological Process Technology, University of Minnesota, St. Paul, Minnesota 55108
The uniporter/symporter/antiporter superfamily is an evolutionarily related group of solute transporters. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains. These transmembrane domains were then analyzed with regard to their overall hydrophobicity and amphipathicity. In addition, the lengths of the hydrophilic loops connecting the transmembrane domains were calculated. These data, together with structural information in the literature, were collectively used to produce a general model for the three-dimensional arrangement of the transmembrane domains.
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