| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Protein Science, Vol 5, Issue 1 162-166, Copyright © 1996 by Cold Spring Harbor Laboratory Press
FOR THE RECORD |
C. P. PONTING and P. J. PARKER
University of Oxford, Fibrinolysis Research Unit, The Old Observatory, South Parks Road, Oxford, OX1 3RH, United Kingdom
Various membrane lipid metabolites, generated by phospholipases C and D (PLCs, PLDs), are known to regulate the activities of protein kinases C (PKCs) and GTP-ase activating proteins (GAPs) in a range of cellular processes. Conventional Ca(2+)-dependent PKCs ({alpha}, {beta}I, {beta}II, and {gamma}), PLCs, and various GAPs are all known to contain copies of a phospholipid-binding domain, termed C2 or CalB. Here we recognize that C2 domains are also present in ``new'' Ca(2+)-independent PKCs ({delta}, {epsilon}, {eta}, and {theta}), other kinases, a eukaryotic PLD, the breakpoint cluster region (BCR) gene product, and two further GAPS. Twenty-two previously unrecognized C2 domain sequences are presented, which include a single copy in the mammalian pore-forming proteins, perforin.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Chalkia, N. Nikolaidis, W. Makalowski, J. Klein, and M. Nei Origins and Evolution of the Formin Multigene Family That Is Involved in the Formation of Actin Filaments Mol. Biol. Evol., December 1, 2008; 25(12): 2717 - 2733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Alzamora, L. R. Brown, and B. J. Harvey Direct Binding and Activation of Protein Kinase C Isoforms by Aldosterone and 17{beta}-Estradiol Mol. Endocrinol., November 1, 2007; 21(11): 2637 - 2650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Herrmann, P. Sprote, and A. A. Brakhage Protein Kinase C (PkcA) of Aspergillus nidulans Is Involved in Penicillin Production Appl. Envir. Microbiol., April 1, 2006; 72(4): 2957 - 2970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Voskoboinik, M.-C. Thia, J. Fletcher, A. Ciccone, K. Browne, M. J. Smyth, and J. A. Trapani Calcium-dependent Plasma Membrane Binding and Cell Lysis by Perforin Are Mediated through Its C2 Domain: A CRITICAL ROLE FOR ASPARTATE RESIDUES 429, 435, 483, AND 485 BUT NOT 491 J. Biol. Chem., March 4, 2005; 280(9): 8426 - 8434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Denis and M. S. Cyert Molecular Analysis Reveals Localization of Saccharomyces cerevisiae Protein Kinase C to Sites of Polarized Growth and Pkc1p Targeting to the Nucleus and Mitotic Spindle Eukaryot. Cell, January 1, 2005; 4(1): 36 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Pappan, L. Zheng, R. Krishnamoorthi, and X. Wang Evidence for and Characterization of Ca2+ Binding to the Catalytic Region of Arabidopsis thaliana Phospholipase D{beta} J. Biol. Chem., November 12, 2004; 279(46): 47833 - 47839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Itani, J. R. Campbell, J. Herrero, P. M. Snyder, and C. P. Thomas Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains Am J Physiol Renal Physiol, November 1, 2003; 285(5): F916 - F929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. McGee, J. L. Roe, T. A. Sweat, X. Wang, J. A. Guikema, and J. E. Leach Rice Phospholipase D Isoforms Show Differential Cellular Location and Gene Induction Plant Cell Physiol., October 15, 2003; 44(10): 1013 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Davis, K. R. Doherty, A. J. Delmonte, and E. M. McNally Calcium-sensitive Phospholipid Binding Properties of Normal and Mutant Ferlin C2 Domains J. Biol. Chem., June 14, 2002; 277(25): 22883 - 22888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. da Rocha, D.R.A. Mans, A. Regner, and G. Schwartsmann Targeting Protein Kinase C: New Therapeutic Opportunities Against High-Grade Malignant Gliomas? Oncologist, February 1, 2002; 7(1): 17 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Hutt, R. A. Cardullo, J. M. Baltz, and J. K. Ngsee Synaptotagmin VIII Is Localized to the Mouse Sperm Head and May Function in Acrosomal Exocytosis Biol Reprod, January 1, 2002; 66(1): 50 - 56. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. C. Gardiner, J. D. I. Harper, N. D. Weerakoon, D. A. Collings, S. Ritchie, S. Gilroy, R. J. Cyr, and J. Marc A 90-kD Phospholipase D from Tobacco Binds to Microtubules and the Plasma Membrane PLANT CELL, September 1, 2001; 13(9): 2143 - 2158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Maarouf, F. Carriere, M. Riviere, and A. Abousalham Functional expression in insect cells, one-step purification and characterization of a recombinant phospholipase D from cowpea (Vigna unguiculata L. Walp) Protein Eng. Des. Sel., November 1, 2000; 13(11): 811 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Plant, F. Lafont, S. Lecat, P. Verkade, K. Simons, and D. Rotin Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin XIIIb J. Cell Biol., June 26, 2000; 149(7): 1473 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Quackenbush, G. W. Reuther, J. P. Miller, K. D. Courtney, W. S. Pear, and A. M. Pendergast Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases Blood, May 1, 2000; 95(9): 2913 - 2921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Frank, T. Munnik, K. Kerkmann, F. Salamini, and D. Bartels Water Deficit Triggers Phospholipase D Activity in the Resurrection Plant Craterostigma plantagineum PLANT CELL, January 1, 2000; 12(1): 111 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang The Role of Phospholipase D in Signaling Cascades Plant Physiology, July 1, 1999; 120(3): 645 - 652. [Full Text]
|
|
|
|
|
|
O. Perisic, H. F. Paterson, G. Mosedale, S. Lara-Gonzalez, and R. L. Williams Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2 J. Biol. Chem., May 21, 1999; 274(21): 14979 - 14987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zeidman, B. Lofgren, S. Pahlman, and C. Larsson PKCepsilon , Via its Regulatory Domain and Independently of its Catalytic Domain, Induces Neurite-like Processes in Neuroblastoma Cells J. Cell Biol., May 17, 1999; 145(4): 713 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Osborne, J. Herreros, P. I. H. Bastiaens, and G. Schiavo Calcium-dependent Oligomerization of Synaptotagmins I and II. SYNAPTOTAGMINS I AND II ARE LOCALIZED ON THE SAME SYNAPTIC VESICLE AND HETERODIMERIZE IN THE PRESENCE OF CALCIUM J. Biol. Chem., January 1, 1999; 274(1): 59 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Arcaro, S. Volinia, M. J. Zvelebil, R. Stein, S. J. Watton, M. J. Layton, I. Gout, K. Ahmadi, J. Downward, and M. D. Waterfield Human Phosphoinositide 3-Kinase C2beta , the Role of Calcium and the C2 Domain in Enzyme Activity J. Biol. Chem., December 4, 1998; 273(49): 33082 - 33090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Davletov, O. Perisic, and R. L. Williams Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically J. Biol. Chem., July 24, 1998; 273(30): 19093 - 19096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rizo and T. C. Sudhof C2-domains, Structure and Function of a Universal Ca2+-binding Domain J. Biol. Chem., June 26, 1998; 273(26): 15879 - 15882. [Full Text] [PDF]
|
|
|
|
|
|
A. G. Kayali, J. Eichhorn, T. Haruta, A. J. Morris, J. G. Nelson, P. Vollenweider, J. M. Olefsky, and N. J. G. Webster Association of the Insulin Receptor with Phospholipase C-gamma (PLCgamma ) in 3T3-L1 Adipocytes Suggests a Role for PLCgamma in Metabolic Signaling by Insulin J. Biol. Chem., May 29, 1998; 273(22): 13808 - 13818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schultz, F. Milpetz, P. Bork, and C. P. Ponting SMART, a simple modular architecture research tool: Identification of signaling domains PNAS, May 26, 1998; 95(11): 5857 - 5864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Flynn, H. Mellor, R. Palmer, G. Panayotou, and P. J. Parker Multiple Interactions of PRK1 with RhoA. FUNCTIONAL ASSIGNMENT OF THE HR1 REPEAT MOTIF J. Biol. Chem., January 30, 1998; 273(5): 2698 - 2705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Nalefski, T. McDonagh, W. Somers, J. Seehra, J. J. Falke, and J. D. Clark Independent Folding and Ligand Specificity of the C2 Calciumdependent Lipid Binding Domain of Cytosolic Phospholipase A2 J. Biol. Chem., January 16, 1998; 273(3): 1365 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Perisic, S. Fong, D. E. Lynch, M. Bycroft, and R. L. Williams Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2 J. Biol. Chem., January 16, 1998; 273(3): 1596 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Plant, H. Yeger, O. Staub, P. Howard, and D. Rotin The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization J. Biol. Chem., December 19, 1997; 272(51): 32329 - 32336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Qin, K. Pappan, and X. Wang Molecular Heterogeneity of Phospholipase D (PLD). CLONING OF PLDgamma AND REGULATION OF PLANT PLDgamma , -beta , AND -alpha BY POLYPHOSPHOINOSITIDES AND CALCIUM J. Biol. Chem., November 7, 1997; 272(45): 28267 - 28273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. V. Dekker and P. J. Parker Regulated Binding of the Protein Kinase C Substrate GAP-43 to the V0/C2 Region of Protein Kinase C-delta J. Biol. Chem., May 9, 1997; 272(19): 12747 - 12753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Pappan, W. Qin, J. H. Dyer, L. Zheng, and X. Wang Molecular Cloning and Functional Analysis of Polyphosphoinositide-dependent Phospholipase D, PLDbeta , from Arabidopsis J. Biol. Chem., March 14, 1997; 272(11): 7055 - 7061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Peng, N. A. Morrice, L. C. Groenen, and R. E.H. Wettenhall Phosphorylation Events Associated with Different States of Activation of a Hepatic Cardiolipin/Protease-activated Protein Kinase. STRUCTURAL IDENTITY TO THE PROTEIN KINASE N-TYPE PROTEIN KINASES J. Biol. Chem., December 13, 1996; 271(50): 32233 - 32240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Glaser, S. Wanaski, C. A. Buser, V. Boguslavsky, W. Rashidzada, A. Morris, M. Rebecchi, S. F. Scarlata, L. W. Runnels, G. D. Prestwich, et al. Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Produces Reversible Inhibition of Phospholipase C by Sequestering Phosphatidylinositol 4,5-Bisphosphate in Lateral Domains J. Biol. Chem., October 18, 1996; 271(42): 26187 - 26193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fukuda, C. Saegusa, E. Kanno, and K. Mikoshiba The C2A Domain of Double C2 Protein gamma Contains a Functional Nuclear Localization Signal J. Biol. Chem., June 29, 2001; 276(27): 24441 - 24444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zheng, R. Krishnamoorthi, M. Zolkiewski, and X. Wang Distinct Ca2+ Binding Properties of Novel C2 Domains of Plant Phospholipase Dalpha and beta J. Biol. Chem., June 23, 2000; 275(26): 19700 - 19706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Kuroda, M. Fukuda, H. Ariga, and K. Mikoshiba The Slp Homology Domain of Synaptotagmin-like Proteins 1-4 and Slac2 Functions as a Novel Rab27A Binding Domain J. Biol. Chem., March 8, 2002; 277(11): 9212 - 9218. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
