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Protein Science, Vol 6, Issue 9 1878-1884, Copyright © 1997 by Cold Spring Harbor Laboratory Press

ARTICLE

Solution structure of drosomycin, the first inducible antifungal protein from insects

C. LANDON, P. SODANO, C. HETRU, J. HOFFMANN and M. PTAK
Centre de Biophysique Moleculaire (UPR 4301 CNRS), CNRS

Drosomycin is the first antifungal protein characterized recently among the broad family of inducible peptides and proteins produced by insects to respond to bacterial or septic injuries. It is a small protein of 44 amino acid residues extracted from Drosophila melanogaster that exhibits a potent activity against filamentous fungi. Its three-dimensional structure in aqueous solution was determined using (1)H 2D NMR. This structure, involving an {alpha}-helix and a twisted three-stranded {beta}-sheet, is stabilized by three disulfide bridges. The corresponding Cysteine Stabilized {alpha}{beta} (CS{alpha}{beta}) motif, which was found in other defense proteins such as the antibacterial insect defensin A, short- and long-chain scorpion toxins, as well as in plant thionins and potent antifungal plant defensins, appears as remarkably persistent along evolution.
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