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Protein Science, Vol 7, Issue 2 376-382, Copyright © 1998 by Cold Spring Harbor Laboratory Press
ARTICLE |
W. T. JENKINS
Department of Chemistry, Indiana University, Bloomington, Indiana 47405
Three simple equations are presented, which describe the variation of protein solubility (S) with changes in salt concentration, in terms of either the salt molality (M), the salt activity (a(x)), or the water activity (a(w)). Each equation yields, essentially independent, estimates of the numbers of salt ions ({Delta}v(x)) and water molecules ({Delta}v(w)) involved in the dissolution of a mol of the protein. The equations can be used to elucidate the physical significance of the parameters in other empirical equations for protein solubility.
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