| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Protein Science, Vol 7, Issue 7 1647-1652, Copyright © 1998 by Cold Spring Harbor Laboratory Press
FOR THE RECORD |
M. C. THALLER, S. SCHIPPA and G. M. ROSSOLINI
Dipartimento di Biologia, Universita di Roma ``Tor Vergata,'' 00133 Rome, Italy
Members of a new molecular family of bacterial nonspecific acid phosphatases (NSAPs), indicated as class C, were found to share significant sequence similarities to bacterial class B NSAPs and to some plant acid phosphatases, representing the first example of a family of bacterial NSAPs that has a relatively close eukaryotic counterpart. Despite the lack of an overall similarity, conserved sequence motifs were also identified among the above enzyme families (class B and class C bacterial NSAPs, and related plant phosphatases) and several other families of phosphohydrolases, including bacterial phosphoglycolate phosphatases, histidinol-phosphatase domains of the bacterial bifunctional enzymes imidazole-glycerolphosphate dehydratases, and bacterial, eukaryotic, and archaeal phosphoserine phosphatases and threalose-6-phosphatases. These conserved motifs are clustered within two domains, separated by a variable spacer region, according to the pattern [FILMAVT]-D-[ILFRMVY]-D-[GSNDE]-[TV]-[ILVAM]-[ATSVILMC]-X-{YFWHKR}-X- {YFWHNQ}-X(102,191)-{KRHNQ}-G-D-{FYWHILVMC}-{QNH}-{FWYGP}-D-{PSNQYW}. The dephosphorylating activity common to all these proteins supports the definition of this phosphatase motif and the inclusion of these enzymes into a superfamily of phosphohydrolases that we propose to indicate as ``DDDD'' after the presence of the four invariant aspartate residues. Database searches retrieved various hypothetical proteins of unknown function containing this or similar motifs, for which a phosphohydrolase activity could be hypothesized.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Delgado, S. Zaman, A. Muthaiyan, V. Nagarajan, M. O. Elasri, B. J. Wilkinson, and J. E. Gustafson The fusidic acid stimulon of Staphylococcus aureus J. Antimicrob. Chemother., December 1, 2008; 62(6): 1207 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Hoopman, W. Wang, C. A. Brautigam, J. L. Sedillo, T. J. Reilly, and E. J. Hansen Moraxella catarrhalis Synthesizes an Autotransporter That Is an Acid Phosphatase J. Bacteriol., February 15, 2008; 190(4): 1459 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Costa, N. Empadinhas, and M. S. da Costa Glucosylglycerate Biosynthesis in the Deepest Lineage of the Bacteria: Characterization of the Thermophilic Proteins GpgS and GpgP from Persephonella marina J. Bacteriol., March 1, 2007; 189(5): 1648 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Rangarajan, A. Proteau, J. Wagner, M.-N. Hung, A. Matte, and M. Cygler Structural Snapshots of Escherichia coli Histidinol Phosphate Phosphatase along the Reaction Pathway J. Biol. Chem., December 8, 2006; 281(49): 37930 - 37941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Costa, N. Empadinhas, L. Goncalves, P. Lamosa, H. Santos, and M. S. da Costa Characterization of the Biosynthetic Pathway of Glucosylglycerate in the Archaeon Methanococcoides burtonii J. Bacteriol., February 1, 2006; 188(3): 1022 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, J.-E. Ahn, S. Datta, R. A. Salzman, J. Moon, B. Huyghues-Despointes, B. Pittendrigh, L. L. Murdock, H. Koiwa, and K. Zhu-Salzman Arabidopsis Vegetative Storage Protein Is an Anti-Insect Acid Phosphatase Plant Physiology, November 1, 2005; 139(3): 1545 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Green, E. Baranyi, T. J. Reilly, A. L. Smith, and G. W. Zlotnick Certain Site-Directed, Nonenzymatically Active Mutants of the Haemophilus influenzae P4 Lipoprotein Are Able To Elicit Bactericidal Antibodies Infect. Immun., July 1, 2005; 73(7): 4454 - 4457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takayama, C. Wang, and G. S. Besra Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis Clin. Microbiol. Rev., January 1, 2005; 18(1): 81 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hausmann, H. Erdjument-Bromage, and S. Shuman Schizosaccharomyces pombe Carboxyl-terminal Domain (CTD) Phosphatase Fcp1: DISTRIBUTIVE MECHANISM, MINIMAL CTD SUBSTRATE, AND ACTIVE SITE MAPPING J. Biol. Chem., March 19, 2004; 279(12): 10892 - 10900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Borges, J. D. Marugg, N. Empadinhas, M. S. d. Costa, and H. Santos Specialized Roles of the Two Pathways for the Synthesis of Mannosylglycerate in Osmoadaptation and Thermoadaptation of Rhodothermus marinus J. Biol. Chem., March 12, 2004; 279(11): 9892 - 9898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wu and R. W. Woodard Escherichia coli YrbI Is 3-Deoxy-D-manno-octulosonate 8-Phosphate Phosphatase J. Biol. Chem., May 9, 2003; 278(20): 18117 - 18123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hausmann and S. Shuman Defining the Active Site of Schizosaccharomyces pombe C-terminal Domain Phosphatase Fcp1 J. Biol. Chem., April 11, 2003; 278(16): 13627 - 13632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Eastmond, Y. Li, and I. A. Graham Is trehalose-6-phosphate a regulator of sugar metabolism in plants? J. Exp. Bot., January 3, 2003; 54(382): 533 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Petters, C. Gobel, D. Scheel, and S. Rosahl A Pathogen-Responsive cDNA from Potato Encodes a Protein with Homology to a Phosphate Starvation-Induced Phosphatase Plant Cell Physiol., September 15, 2002; 43(9): 1049 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Petrucco, G. Volpi, A. Bolchi, C. Rivetti, and S. Ottonello A Nick-sensing DNA 3'-Repair Enzyme from Arabidopsis J. Biol. Chem., June 21, 2002; 277(26): 23675 - 23683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hausmann and S. Shuman Characterization of the CTD Phosphatase Fcp1 from Fission Yeast. PREFERENTIAL DEPHOSPHORYLATION OF SERINE 2 VERSUS SERINE 5 J. Biol. Chem., June 7, 2002; 277(24): 21213 - 21220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Van Dijck, L. De Rop, K. Szlufcik, E. Van Ael, and J. M. Thevelein Disruption of the Candida albicans TPS2 Gene Encoding Trehalose-6-Phosphate Phosphatase Decreases Infectivity without Affecting Hypha Formation Infect. Immun., April 1, 2002; 70(4): 1772 - 1782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Wang and S. Shuman Mutational analysis defines the 5'-kinase and 3'-phosphatase active sites of T4 polynucleotide kinase Nucleic Acids Res., February 15, 2002; 30(4): 1073 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Vance and T. E. Wilson Repair of DNA Strand Breaks by the Overlapping Functions of Lesion-Specific and Non-Lesion-Specific DNA 3' Phosphatases Mol. Cell. Biol., November 1, 2001; 21(21): 7191 - 7198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kemmer, T. J. Reilly, J. Schmidt-Brauns, G. W. Zlotnik, B. A. Green, M. J. Fiske, M. Herbert, A. Krai{beta}, S. Schlor, A. Smith, et al. NadN and e (P4) Are Essential for Utilization of NAD and Nicotinamide Mononucleotide but Not Nicotinamide Riboside in Haemophilus influenzae J. Bacteriol., July 1, 2001; 183(13): 3974 - 3981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lei, S. Mackie, S. Lukomski, and J. M. Musser Identification and Immunogenicity of Group A Streptococcus Culture Supernatant Proteins Infect. Immun., December 1, 2000; 68(12): 6807 - 6818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Saleh and J. T. Belisle Secretion of an Acid Phosphatase (SapM) by Mycobacterium tuberculosis That Is Similar to Eukaryotic Acid Phosphatases J. Bacteriol., December 1, 2000; 182(23): 6850 - 6853. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Mihara, T. Utagawa, H. Yamada, and Y. Asano Phosphorylation of Nucleosides by the Mutated Acid Phosphatase from Morganella morganii Appl. Envir. Microbiol., July 1, 2000; 66(7): 2811 - 2816. [Abstract] [Full Text]
|
|
|
|
|
|
S. Kawasaki, C. Miyake, T. Kohchi, S. Fujii, M. Uchida, and A. Yokota Responses of Wild Watermelon to Drought Stress: Accumulation of an ArgE Homologue and Citrulline in Leaves during Water Deficits Plant Cell Physiol., July 1, 2000; 41(7): 864 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Collet, V. Stroobant, and E. Van Schaftingen Mechanistic Studies of Phosphoserine Phosphatase, an Enzyme Related to P-type ATPases J. Biol. Chem., November 26, 1999; 274(48): 33985 - 33990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Reilly, D. L. Chance, and A. L. Smith Outer Membrane Lipoprotein e (P4) of Haemophilus influenzae Is a Novel Phosphomonoesterase J. Bacteriol., November 1, 1999; 181(21): 6797 - 6805. [Abstract] [Full Text]
|
|
|
|
|
|
D. le Coq, S. Fillinger, and S. Aymerich Histidinol Phosphate Phosphatase, Catalyzing the Penultimate Step of the Histidine Biosynthesis Pathway, Is Encoded by ytvP (hisJ) in Bacillus subtilis J. Bacteriol., May 15, 1999; 181(10): 3277 - 3280. [Abstract] [Full Text]
|
|
|
|
|
|
M. Betti, S. Petrucco, A. Bolchi, G. Dieci, and S. Ottonello A Plant 3'-Phosphoesterase Involved in the Repair of DNA Strand Breaks Generated by Oxidative Damage J. Biol. Chem., May 18, 2001; 276(21): 18038 - 18045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Vance and T. E. Wilson Uncoupling of 3'-Phosphatase and 5'-Kinase Functions in Budding Yeast. CHARACTERIZATION OF SACCHAROMYCES CEREVISIAE DNA 3'-PHOSPHATASE (TPP1) J. Biol. Chem., April 27, 2001; 276(18): 15073 - 15081. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
