|
|
||||||||
Protein Science, Vol 9, Issue 10 1930-1934, Copyright © 2000 by The Protein Society
P Mahon and A Bateman
Department of Biochemistry, University of Cambridge, United Kingdom.
We have identified a similarity between the apical domain of the human transferrin receptor and several other protein families. This domain is found associated with two different families of peptidases. Therefore, we term it the PA domain for protease-associated domain. The PA domain is found inserted within a loop of the peptidase domain of family M8/M33 zinc peptidases. The PA domain is also found in a vacuolar sorting receptor and a ring finger protein of unknown function that may be a cell surface receptor. The PA domain may mediate substrate determination of peptidases or form protein-protein interactions.
This article has been cited by other articles:
![]() |
N. Lineberry, L. Su, L. Soares, and C. G. Fathman The Single Subunit Transmembrane E3 Ligase Gene Related to Anergy in Lymphocytes (GRAIL) Captures and Then Ubiquitinates Transmembrane Proteins across the Cell Membrane J. Biol. Chem., October 17, 2008; 283(42): 28497 - 28505. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. B. Lineberry, L. L. Su, J. T. Lin, G. P. Coffey, C. M. Seroogy, and C. G. Fathman Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy J. Immunol., August 1, 2008; 181(3): 1622 - 1626. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. L. Avila, M. Brown, S. Pan, R. Desikan, S. J. Neill, T. Girke, M. Surpin, and N. V. Raikhel Expression analysis of Arabidopsis vacuolar sorting receptor 3 reveals a putative function in guard cells J. Exp. Bot., April 1, 2008; 59(6): 1149 - 1161. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. K. Brown, Z.-Y. Gu, Y. V. Matsuka, S. S. Purushothaman, L. A. Winter, P. P. Cleary, S. B. Olmsted, D. H. Ohlendorf, and C. A. Earhart Structure of the streptococcal cell wall C5a peptidase PNAS, December 20, 2005; 102(51): 18391 - 18396. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. I. Davis, M. J. Bennett, L. M. Thomas, and P. J. Bjorkman Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase PNAS, April 26, 2005; 102(17): 5981 - 5986. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. W. Mast, K. Diekman, K. Karaveg, A. Davis, R. N. Sifers, and K. W. Moremen Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins Glycobiology, April 1, 2005; 15(4): 421 - 436. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Faraco, G. Palmieri, G. Festa, M. Monti, G. Sannia, and P. Giardina A new subfamily of fungal subtilases: structural and functional analysis of a Pleurotus ostreatus member Microbiology, February 1, 2005; 151(2): 457 - 466. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Guais, B. Solhonne, N. Melaine, G. Guellaen, and F. Bulle Goliath, a Ring-H2 Mitochondrial Protein, Regulated by Luteinizing Hormone/Human Chorionic Gonadotropin in Rat Leydig Cells Biol Reprod, January 1, 2004; 70(1): 204 - 213. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Martoglio and T. E. Golde Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs Hum. Mol. Genet., October 15, 2003; 12(90002): R201 - 206. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Xia and M. S. Wolfe Intramembrane proteolysis by presenilin and presenilin-like proteases J. Cell Sci., July 15, 2003; 116(14): 2839 - 2844. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. E. Golde and C. B. Eckman Physiologic and Pathologic Events Mediated by Intramembranous and Juxtamembranous Proteolysis Sci. Signal., March 4, 2003; 2003(172): re4 - re4. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. P. Ponting, M. Hutton, A. Nyborg, M. Baker, K. Jansen, and T. E. Golde Identification of a novel family of presenilin homologues Hum. Mol. Genet., May 1, 2002; 11(9): 1037 - 1044. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |