Proteins can convert to -sheet in single crystals
Protein Sci Zheng et al.
13: 1288
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Fig. 1: Time-dependent Raman spectra of 5S protein subunit after changing pH from 6.5 to 4.5 in the mother liquor, and Raman spectra for 12S subunit before (red color) and after (purple color) adding the two substrates methylmalonyl-CoA and biotin to the mother liquor.
Fig. 2: Staining the 5S crystals with thioflavin S. Fig. 3: Staining the insulin crystals with thioflavin T.