Disulfide locked variants of factor VIIa with a restricted -strand conformation have enhanced enzymatic activity
Protein Sci Maun et al.
14: 1171
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Figure legend. Trypsin digestion of FVIIa produced a Gla domain peptide (Tryptic peptide: ANAFLXLRPGSLXRXCKXXQCSFXXARXIFK
where X=Gla) containing 9 of the 10 sites of potential Gla
modifications. Representative MALDI-TOF analysis shows similar
patterns and extents of modification between wild type and
S139C:V157C mutant. Other mutants displayed the same pattern.