On the nucleation of amyloid -protein monomer folding

Supplemental Research Data

Files in this Data Supplement:

• Adobe PDF File (6.62 MB) - Results of limited proteolysis of Abeta(1-40) and Abeta(1-42) by chymotrypsin, endoproteinase Asp-N, endoproteinase Glu-C, human neutrophil elastase, porcine pancreatic elastase, and trypsin, and of Abeta(1-42) by thermolysin, are presented. CD spectroscopy of Abeta(21-30), uperimpositions of 25 calculated backbone structures for each of two different families of Abeta(21-30) conformers, angular order parameter analyses of the Abeta(21-30) structure, and tables showing the 1H chemical shifts and structural statistics of Abeta(21-30) also are included.