About the Cover
Cover Illustration: Illustration of H/D exchange protection factors for a mutant, cancer-associated form of the p53 tetramerization domain (R337H). The yellow and orange stripes represents backbone amide protons, which are much more susceptible to exchange in this mutant domain compared to the wild type. Increased rates of H/D exchange are correlated with a general instability of the mutant domain and a heightened propensity to form amyloid fibrils in vitro (EMimage shown in background; courtesy of K. Barnes and G. Murti, St. Jude Children's Research Hospital). These results may have relevance to the accumulation of dysfunctional p53-R337H in pediatric adrenal tumors. (See Galea et al., pp. 2993-3003.)
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Copyright © 2005 by The Protein Society.
