About the Cover
Cover Illustration: Eye lens crystallin proteins have to last a lifetime. The ß-γ -crystallin domain is the repeating module in the family of lens ß- and γ-crystallins. It has a complex topology formed from two similar intercalating Greek key motifs (shown in red and in blue). A predominant family member, ßB2-crystallin, has a cysteine in a folded ß-hairpin (shown in green on the red motif). Molecular dynamics simulations combined with solution experiments have shown local flexibility in this region that can be stabilized by replacement of the cysteine with an aromatic residue that is conserved in other family members. (See MacDonald et al., pp. 1282-1292.)
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Copyright © 2005 by The Protein Society.
