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Cover Illustration: Like the protein-folding dilemma, virus assembly can be described in terms of every possible intermediate and every possible path between intermediates. But not all paths are created equal. Only the most probable and the most stable intermediates make a significant contribution to assembly. In this reaction landscape for a model capsid, the intermediates are spread in three dimensions: n, the number of subunits in the intermediate; ΔG/n, the average free energy per intermediate; and logP, the log of the probability of an intermediate. (See Endres et al., pp. 1518-1525.)
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