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Cover Illustration: Comparison of the Src kinase catalytic domain in the activated (gold) and down-regulated (blue) forms illustrates the interdependent motion of sequentially distant regions. The active conformation of the α-helix interferes with loop closure, as shown by the steric clash between the α-helix (gold) and the loop (blue) in the middle part of the figure. Glutamic acid residue (red) on the α-helix couples the activation transition of the helix and the loop. (See Ozkirimli et al., pp. 1051–1062.)