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Cover Illustration: Percentage of family-specific fingerprints from each of 20 selected TIM barrel families (rows) occurring in the average member of each of the selected families (columns). Percentages are color-coded: blue squares off the diagonal indicate <30% fingerprints shared by most pairs of families, and orange or red squares near the diagonal indicate >70% fingerprints found in members of the same family or families with overlapping members. Thus, fingerprints can distinguish families with very similar structure but different functions. (See Bandyopadhyay et al., pp. 1537–1543.)