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Cover Illustration: The building blocks of the polydisperse eye lens β-crystallins are dimers. Shown here is the dimer-dimer assembly of the 2-domain human βB2-crystallin, which exhibits domain swapping. In the foreground are four colored domains from four different polypeptide chains with the domain swapped monomer-monomer interface positioned about the vertical axis. The related human βB1-crystallin does not domain swap, but forms a dimer about the horizontal interface. Mutations to selected charged side chains, which change ion pair partners depending on the type of domain assembly, have been appended to the domain swapped interface. (See Smith et al., pp. 615–625.)