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Cover Illustration: MHC class I molecules are localized on the surface of most cells and present peptides to CD8+ cytotoxic T-cells. Shown here are 29 superimposed HLA–A*0201 complexes with presented peptides. For the superimposition the β-sheet floors of the binding grooves were aligned. The similar backbone position of the single peptides can be seen. This is a major prerequisite for modelling new peptides into the binding groove using a side chain substitution tool. The α₁ helix of the MHC is hidden to allow direct insight into the binding groove. The MHC α-chain and β₂-microglobulin are shown in white while various colors indicate the backbones of the 29 peptides. (For details, see Knapp et al., pp. 977–982.)