Protein folding dynamics: The diffusion‐collision model and experimental data

The diffusion‐collision model of protein folding is assessed. A description is given of the qualitative aspects and quantitative results of the diffusion‐collision model and their relation to available experimental data. We consider alternative mechanisms for folding and point out their relationship to the diffusion‐collision model. We show that the diffusion‐collision model is supported by a growing body of experimental and theoretical evidence, and we outline future directions for developing the model and its applications.