ReviewKnitting and untying the protein network: Modulation of protein ensembles as a therapeutic strategy |
| Susana Gordo 1, Ernest Giralt 1 2 * |
1Institute for Research in Biomedicine, Parc Científic de Barcelona, Baldiri i Reixac 10, 08028 Barcelona, Spain
2Department of Organic Chemistry, Universitat de Barcelona, Martí i Franqués 1, 08028 Barcelona, Spain
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| email: Ernest Giralt (ernest.giralt@irbbarcelona.org) |
*Correspondence to Ernest Giralt, Institute for Research in Biomedicine, Parc Científic de Barcelona, Baldiri i Reixac 10, 08028 Barcelona, Spain
Funded by:
Plan Nacional del Ministerio de Educación y Ciencia; Grant Number: BIO2008-0799
Generalitat de Catalunya - Xarxa de Referencia en Biotechnologia
| the protein network protein-protein interactions protein interfaces surface recognition drug discovery protein p53 |
| Proteins constitute the working machinery and structural support of all organisms. In performing a given function, they must adopt highly specific structures that can change with their level of activity, often through the direct or indirect action of other proteins. Indeed, proteins typically function within an ensemble, rather than individually. Hence, they must be sufficiently flexible to interact with each other and execute diverse tasks. The discovery that errors within these groups can ultimately cause disease has led to a paradigm shift in drug discovery, from an emphasis on single protein targets to a holistic approach whereby entire ensembles are targeted. |
Received: 11 July 2008; Revised: 16 October 2008; Accepted: 24 November 2008
10.1002/pro.43
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