Protein and Nucleic Acid Coordinates. Atomic coordinates and X-ray structure factors for three-dimensional protein structures must be deposited, before acceptance of the manuscript, with the Protein Data Bank (by FTP at ftp.rcsb.org or WWW at www.rcsb.org; fill out /pub/dep_form.txt) in order for a file identification code to be assigned and published in the article. Protein Science requires, as a condition for publication, that coordinates be publicly released no later than the publication date of the article. Coordinates may need to be made available for the reviewers. If so they will be treated confidentially, as any information in the papers under review.

Authors are strongly encouraged, but not required, to deposit in the Protein Data Bank NMR assignments and lists of NOE constraints and related data.

Data deposition requirements. Protein and Nucleic Acid Sequences. Protein sequence data must be deposited, prior to manuscript submission, with the Protein Identification Resource (PIR) (National Biomedical Research Foundation, Georgetown University Medical Center, Washington, DC 20007, USA). Authors must certify in writing that this sequence has been scanned against this (or other comparable) database(s) and that all identities or significant similarities, including species variation, with other entries have been reported in the manuscript. Nucleotide sequence data must be included as part of manuscript submission and also, prior to manuscript acceptance, must be sent by the author to GenBank Submissions (M.S. K-710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA).

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